Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

Akt-deficiency causes resistance to replicative senescence, oxidative stress- or oncogenic Ras-induced premature senescence, and to reactive oxygen species (ROS)-mediated apoptosis. Akt activation induces premature senescence and sensitizes cells to ROS-mediated apoptosis by increasing intracellular...

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Hlavní autoři: Nogueira, Veronique, Park, Youngkyu, Chen, Chia-Chen, Xu, Pei-Zhang, Chen, Mei-Ling, Tonic, Ivana, Unterman, Terry, Hay, Nissim
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038665/
https://ncbi.nlm.nih.gov/pubmed/19061837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.11.003
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