Akt Activation Emulates Chk1 Inhibition and Bcl2 Overexpression and Abrogates G2 Cell Cycle Checkpoint by Inhibiting BRCA1 Foci

Akt is perhaps the most frequently activated oncoprotein in human cancers. Overriding cell cycle checkpoint in combination with the inhibition of apoptosis are two principal requirements for predisposition to cancer. Here we show that the activation of Akt is sufficient to promote these two principa...

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Autores principales: Tonic, Ivana, Yu, Wan-Ni, Park, Youngku, Chen, Chia-Chen, Hay, Nissim
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911328/
https://ncbi.nlm.nih.gov/pubmed/20495005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104372
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