Hypoxia Selects Bortezomib-Resistant Stem Cells of Chronic Myeloid Leukemia

We previously demonstrated that severe hypoxia inhibits growth of Chronic Myeloid Leukemia (CML) cells and selects stem cells where BCR/Abl(protein) is suppressed, although mRNA is not, so that hypoxia-selected stem cells, while remaining leukemic, are independent of BCR/Abl signaling and thereby re...

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Autori principali: Tanturli, Michele, Giuntoli, Serena, Barbetti, Valentina, Rovida, Elisabetta, Dello Sbarba, Persio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037943/
https://ncbi.nlm.nih.gov/pubmed/21347297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017008
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