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Hypoxia Selects Bortezomib-Resistant Stem Cells of Chronic Myeloid Leukemia
We previously demonstrated that severe hypoxia inhibits growth of Chronic Myeloid Leukemia (CML) cells and selects stem cells where BCR/Abl(protein) is suppressed, although mRNA is not, so that hypoxia-selected stem cells, while remaining leukemic, are independent of BCR/Abl signaling and thereby re...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037943/ https://ncbi.nlm.nih.gov/pubmed/21347297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017008 |
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