Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate

BACKGROUND: Incubation of chronic myeloid leukemia cells in hypoxia inhibits growth and selects BCR/Abl-independent cells with stem cell properties which are refractory to imatinib-mesylate. This study aimed to characterize the relationship of this refractoriness with glucose availability in the env...

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Detalhes bibliográficos
Main Authors: Giuntoli, Serena, Tanturli, Michele, Di Gesualdo, Federico, Barbetti, Valentina, Rovida, Elisabetta, Dello Sbarba, Persio
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031687/
https://ncbi.nlm.nih.gov/pubmed/21071498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.029082
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