Polyelectrolyte Complex Optimization for Macrophage Delivery of Redox Enzyme Nanoparticles

BACKGROUND: We posit that cell-mediated drug delivery can improve transport of therapeutic enzymes to the brain and decrease inflammation and neurodegeneration induced during Parkinson’s disease. Our prior work demonstrated that macrophages loaded with nanoformulated catalase (“nanozyme”) protect th...

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Main Authors: Zhao, Yuling, Haney, Matthew J., Klyachko, Natalia L., Li, Shu, Booth, Stephanie L., Higginbotham, Sheila M., Jones, Jocelyn, Zimmerman, Matthew C., Mosley, R. Lee, Kabanov, Alexander V., Gendelman, Howard E., Batrakova, Elena V.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037278/
https://ncbi.nlm.nih.gov/pubmed/21182416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.10.129
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