Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases

The ability to precisely upregulate genes in inflamed brain holds great therapeutic promise. Here we report a novel class of vectors, genetically modified macrophages that carry reporter and therapeutic genes to neural cells. Systemic administration of macrophages transfected ex vivo with a plasmid...

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Hlavní autoři: Haney, Matthew J., Zhao, Yuling, Harrison, Emily B., Mahajan, Vivek, Ahmed, Shaheen, He, Zhijian, Suresh, Poornima, Hingtgen, Shawn D., Klyachko, Natalia L., Mosley, R. Lee, Gendelman, Howard E., Kabanov, Alexander V., Batrakova, Elena V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631190/
https://ncbi.nlm.nih.gov/pubmed/23620794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061852
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