Functional Screening of Alzheimer Pathology Genome-wide Association Signals in Drosophila

We have leveraged a Drosophila model relevant to Alzheimer disease (AD) for functional screening of findings from a genome-wide scan for loci associated with a quantitative measure of AD pathology in humans. In six of the 15 genomic regions evaluated, we successfully identified a causal gene for the...

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Autori principali: Shulman, Joshua M., Chipendo, Portia, Chibnik, Lori B., Aubin, Cristin, Tran, Dong, Keenan, Brendan T., Kramer, Patricia L., Schneider, Julie A., Bennett, David A., Feany, Mel B., De Jager, Philip L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035702/
https://ncbi.nlm.nih.gov/pubmed/21295279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.01.006
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