Functional Screening of Alzheimer Pathology Genome-wide Association Signals in Drosophila

We have leveraged a Drosophila model relevant to Alzheimer disease (AD) for functional screening of findings from a genome-wide scan for loci associated with a quantitative measure of AD pathology in humans. In six of the 15 genomic regions evaluated, we successfully identified a causal gene for the...

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Detalhes bibliográficos
Main Authors: Shulman, Joshua M., Chipendo, Portia, Chibnik, Lori B., Aubin, Cristin, Tran, Dong, Keenan, Brendan T., Kramer, Patricia L., Schneider, Julie A., Bennett, David A., Feany, Mel B., De Jager, Philip L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035702/
https://ncbi.nlm.nih.gov/pubmed/21295279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.01.006
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