Genetic modifiers of tauopathy in Drosophila.

In Alzheimer's disease and related disorders, the microtubule-associated protein Tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles. Mutations in the tau gene cause familial frontotemporal dementia. To investigate the molecular mechanisms responsible for Tau-induc...

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Bibliographic Details
Main Authors: Shulman, Joshua M, Feany, Mel B
Format: Artigo
Language:Inglês
Published: 2003
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462852/
https://ncbi.nlm.nih.gov/pubmed/14668378
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