Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

Using a Drosophila model of Alzheimer's disease (AD), we systematically evaluated 67 candidate genes based on AD-associated genomic loci (P < 10(−4)) from published human genome-wide association studies (GWAS). Genetic manipulation of 87 homologous fly genes was tested for modulation of neur...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shulman, Joshua M., Imboywa, Selina, Giagtzoglou, Nikolaos, Powers, Martin P., Hu, Yanhui, Devenport, Danelle, Chipendo, Portia, Chibnik, Lori B., Diamond, Allison, Perrimon, Norbert, Brown, Nicholas H., De Jager, Philip L., Feany, Mel B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2014
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900103/
https://ncbi.nlm.nih.gov/pubmed/24067533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt478
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