Optimizing anti-gene oligonucleotide ‘Zorro-LNA’ for improved strand invasion into duplex DNA

Zorro-LNA (Zorro) is a newly developed, oligonucleotide (ON)-based, Z-shaped construct with the potential of specific binding to each strand of duplex DNA. The first-generation Zorros are formed by two hybridized LNA/DNA mixmers (2-ON Zorros) and was hypothesized to strand invade. We have now establ...

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Main Authors: Zaghloul, Eman M., Madsen, Andreas S., Moreno, Pedro M. D., Oprea, Iulian I., El-Andaloussi, Samir, Bestas, Burcu, Gupta, Pankaj, Pedersen, Erik B., Lundin, Karin E., Wengel, Jesper, Smith, C. I. Edvard
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Synthetic Biology and Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035455/
https://ncbi.nlm.nih.gov/pubmed/20860997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq835
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