The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy

Two major pathways contribute to Ras-proximate-1–mediated integrin activation in stimulated platelets. Calcium and diacyglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI, RasGRP2) mediates the rapid but reversible activation of integrin αIIbβ3, while the adenosine diphosphate rece...

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Detalhes bibliográficos
Main Authors: Stolla, Moritz, Stefanini, Lucia, Roden, R. Claire, Chavez, Massiel, Hirsch, Jessica, Greene, Teshell, Ouellette, Timothy D., Maloney, Sean F., Diamond, Scott L., Poncz, Mortimer, Woulfe, Donna S., Bergmeier, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035063/
https://ncbi.nlm.nih.gov/pubmed/20971951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-297713
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