Multiple tissues express alpha 1-antitrypsin in transgenic mice and man.

Hepatocytes are considered to be the predominant source of alpha 1-antitrypsin (AAT), the major antiprotease in human plasma. The development of emphysema in the hereditary PiZ AAT deficiency state suggests that inhibition of leukocyte elastase in the lung is a major function of this protein. In add...

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Pubblicato in:	J Clin Invest
Autori principali:	Carlson, J A, Rogers, B B, Sifers, R N, Hawkins, H K, Finegold, M J, Woo, S L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303472/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3260605/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113580
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