Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice.

Circulating alpha 1-antitrypsin is synthesized primarily in the liver and secreted into the bloodstream, where it serves as the major protease inhibitor. The PiZ variant of alpha 1-antitrypsin is associated with decreased levels of the protein in sera as a result of its retention within hepatocytes....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Carlson, J A, Rogers, B B, Sifers, R N, Finegold, M J, Clift, S M, DeMayo, F J, Bullock, D W, Woo, S L
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1989
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC303805/
https://ncbi.nlm.nih.gov/pubmed/2784798
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