Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice.

Circulating alpha 1-antitrypsin is synthesized primarily in the liver and secreted into the bloodstream, where it serves as the major protease inhibitor. The PiZ variant of alpha 1-antitrypsin is associated with decreased levels of the protein in sera as a result of its retention within hepatocytes....

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Bibliographic Details
Main Authors: Carlson, J A, Rogers, B B, Sifers, R N, Finegold, M J, Clift, S M, DeMayo, F J, Bullock, D W, Woo, S L
Format: Artigo
Language:Inglês
Published: 1989
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC303805/
https://ncbi.nlm.nih.gov/pubmed/2784798
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