Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice.

Circulating alpha 1-antitrypsin is synthesized primarily in the liver and secreted into the bloodstream, where it serves as the major protease inhibitor. The PiZ variant of alpha 1-antitrypsin is associated with decreased levels of the protein in sera as a result of its retention within hepatocytes....

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Publicat a:	J Clin Invest
Autors principals:	Carlson, J A, Rogers, B B, Sifers, R N, Finegold, M J, Clift, S M, DeMayo, F J, Bullock, D W, Woo, S L
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 1989
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2784798/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113999
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