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Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs
Shp2 protein tyrosine phosphate (PTP) is a novel target for anticancer drug discovery. We identified estramustine phosphate as a Shp2 PTP inhibitor from the National Cancer Institute Approved Oncology Drug set. A focused structure-activity relationship study indicated that the 17- phosphate group is...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034307/ https://ncbi.nlm.nih.gov/pubmed/21193311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.117 |
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