Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs

Shp2 protein tyrosine phosphate (PTP) is a novel target for anticancer drug discovery. We identified estramustine phosphate as a Shp2 PTP inhibitor from the National Cancer Institute Approved Oncology Drug set. A focused structure-activity relationship study indicated that the 17- phosphate group is...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Scott, Latanya M., Chen, Liwei, Daniel, Kenyon G., Brooks, Wesley H., Guida, Wayne C., Lawrence, Harshani R., Sebti, Said M., Lawrence, Nicholas J., Wu, Jie
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034307/
https://ncbi.nlm.nih.gov/pubmed/21193311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.117
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki