Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs

Shp2 protein tyrosine phosphate (PTP) is a novel target for anticancer drug discovery. We identified estramustine phosphate as a Shp2 PTP inhibitor from the National Cancer Institute Approved Oncology Drug set. A focused structure-activity relationship study indicated that the 17- phosphate group is...

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Main Authors: Scott, Latanya M., Chen, Liwei, Daniel, Kenyon G., Brooks, Wesley H., Guida, Wayne C., Lawrence, Harshani R., Sebti, Said M., Lawrence, Nicholas J., Wu, Jie
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034307/
https://ncbi.nlm.nih.gov/pubmed/21193311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.117
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