Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

The Carma1–Bcl10–Malt1 (CBM) complex bridges T-cell receptor (TCR) signalling to the canonical IκB kinase (IKK)/NF-κB pathway. NF-κB activation is triggered by PKCθ-dependent phosphorylation of Carma1 after TCR/CD28 co-stimulation. PKCθ-phosphorylated Carma1 was suggested to function as a molecular...

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Main Authors: Eitelhuber, Andrea C, Warth, Sebastian, Schimmack, Gisela, Düwel, Michael, Hadian, Kamyar, Demski, Katrin, Beisker, Wolfgang, Shinohara, Hisaaki, Kurosaki, Tomohiro, Heissmeyer, Vigo, Krappmann, Daniel
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034008/
https://ncbi.nlm.nih.gov/pubmed/21157432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.331
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