PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

The B cell antigen receptor (BCR)–mediated activation of IκB kinase (IKK) and nuclear factor–κB require protein kinase C (PKC)β; however, the mechanism by which PKCβ regulates IKK is unclear. Here, we demonstrate that another protein kinase, TGFβ-activated kinase (TAK)1, is essential for IKK activat...

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Main Authors: Shinohara, Hisaaki, Yasuda, Tomoharu, Aiba, Yuichi, Sanjo, Hideki, Hamadate, Megumi, Watarai, Hiroshi, Sakurai, Hiroaki, Kurosaki, Tomohiro
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212994/
https://ncbi.nlm.nih.gov/pubmed/16301747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051591
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