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Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation

The transcription factor nuclear factor-κB (NF-κB) signaling pathway is crucial in B-cell physiology. One key molecule regulating this pathway is the serine/threonine kinase TAK1 (MAP3K7). TAK1 is responsible for positive feedback mechanisms in B-cell receptor signaling that serve as an NF-κB activa...

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Detalhes bibliográficos
Publicado no:Immunol Cell Biol
Main Authors: Shinohara, Hisaaki, Kurosaki, Tomohiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073155/
https://ncbi.nlm.nih.gov/pubmed/27121163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2016.44
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