2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP(+)-Dependent Isocitrate Dehydrogenase Mutations

BACKGROUND: Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2 R172 in glioma patients. Genetic...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jin, Genglin, Reitman, Zachary J., Spasojevic, Ivan, Batinic-Haberle, Ines, Yang, Jian, Schmidt-Kittler, Oleg, Bigner, Darell D., Yan, Hai
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033901/
https://ncbi.nlm.nih.gov/pubmed/21326614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016812
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares