ELEVATED COPPER REMODELS HEPATIC RNA PROCESSING MACHINERY IN THE MOUSE MODEL OF WILSON'S DISEASE

Copper is essential to mammalian physiology and its homeostasis is tightly regulated. In humans, genetic defects in copper excretion result in copper overload and Wilson's disease (WD). Previous studies in the mouse model for WD (Atp7b(-/-)) revealed copper accumulation in hepatic nuclei and sp...

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Hlavní autoři: Burkhead, Jason L., Ralle, Martina, Wilmarth, Phillip, David, Larry, Lutsenko, Svetlana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033566/
https://ncbi.nlm.nih.gov/pubmed/21146535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.12.001
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