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Altered zinc balance in the Atp7b(−/−) mouse model reveals a mechanism of copper toxicity in Wilson Disease
Wilson Disease (WD) is an autosomal recessive disorder caused by mutation in the ATP7B gene that affects copper transport in the body. ATP7B mutation damages copper transporter function, ultimately resulting in excessive copper accumulation and subsequent toxicity in both the liver and brain. Mechan...
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| Publicado no: | Metallomics |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6310031/ https://ncbi.nlm.nih.gov/pubmed/30277246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8mt00199e |
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