Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6(R611C) increases PDGF-dependent vascular smooth muscle cell proliferation

Vascular smooth muscle cell (VSMC) proliferation is an important event in atherosclerosis and other vasculopathies. PDGF signaling is a key mediator of SMC proliferation, but the mechanisms that control its activity remain unclear. We previously identified a mutation in LDL receptor-related protein...

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Bibliographic Details
Main Authors: Keramati, Ali R., Singh, Rajvir, Lin, Aiping, Faramarzi, Saeed, Ye, Zhi-jia, Mane, Shrikant, Tellides, George, Lifton, Richard P., Mani, Arya
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033290/
https://ncbi.nlm.nih.gov/pubmed/21245321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019443108
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