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Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6(R611C) increases PDGF-dependent vascular smooth muscle cell proliferation
Vascular smooth muscle cell (VSMC) proliferation is an important event in atherosclerosis and other vasculopathies. PDGF signaling is a key mediator of SMC proliferation, but the mechanisms that control its activity remain unclear. We previously identified a mutation in LDL receptor-related protein...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3033290/ https://ncbi.nlm.nih.gov/pubmed/21245321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019443108 |
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