Virtual Ligand Screening of the National Cancer Institute (NCI) Compound Library Leads to the Allosteric Inhibitory Scaffolds of the West Nile Virus NS3 Proteinase

Viruses of the genus Flavivirus are responsible for significant human disease and mortality. The N-terminal domain of the flaviviral nonstructural (NS)3 protein codes for the serine, chymotrypsin-fold proteinase (NS3pro). The presence of the nonstructural (NS)2B cofactor, which is encoded by the ups...

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Hlavní autoři: Shiryaev, Sergey A., Cheltsov, Anton V., Gawlik, Katarzyna, Ratnikov, Boris I., Strongin, Alex Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2011
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033206/
https://ncbi.nlm.nih.gov/pubmed/21050032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2010.0309
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