Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

Posttranslational modification of metazoan nucleocytoplasmic proteins with N-acetylglucosamine (O-GlcNAc) is essential, dynamic, and inducible and can compete with protein phosphorylation in signal transduction. Inhibitors of O-GlcNAcase, the enzyme removing O-GlcNAc, are useful tools for studying t...

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Autori principali: Dorfmueller, Helge C., Borodkin, Vladimir S., Schimpl, Marianne, Zheng, Xiaowei, Kime, Robert, Read, Kevin D., van Aalten, Daan M.F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032886/
https://ncbi.nlm.nih.gov/pubmed/21095575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.09.014
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