The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508

Relative contributions of folding kinetics versus protein quality control (QC) activity in the partitioning of non-native proteins between life and death are not clear. Cystic fibrosis transmembrane conductance regulator (CFTR) biogenesis serves as an excellent model to study this question because f...

Full description

Saved in:
Bibliographic Details
Main Authors: Grove, Diane E., Fan, Chun-Yang, Ren, Hong Yu, Cyr, Douglas M.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2011
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031462/
https://ncbi.nlm.nih.gov/pubmed/21148293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-09-0760
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items