Lyn- and PLC-β3–dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease

Hyperactivation of the transcription factor Stat5 leads to various leukemias. Stat5 activity is regulated by the protein phosphatase SHP-1 in a phospholipase C (PLC)–β3-dependent manner. Thus, PLC-β3–deficient mice develop myeloproliferative neoplasm, like Lyn (Src family kinase)– deficient mice. He...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Xiao, Wenbin, Ando, Tomoaki, Wang, Huan-You, Kawakami, Yuko, Kawakami, Toshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031387/
https://ncbi.nlm.nih.gov/pubmed/20858858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-283937
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados