Mutations in CBL occur frequently in juvenile myelomonocytic leukemia

Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Seventy-five percent of patients harbor mutations in the NF1, NRAS, KRAS, or PTPN11 genes,...

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Autors principals: Loh, Mignon L., Sakai, Debbie S., Flotho, Christian, Kang, Michelle, Fliegauf, Manfred, Archambeault, Sophie, Mullighan, Charles G., Chen, Leslie, Bergstraesser, Eva, Bueso-Ramos, Carlos E., Emanuel, Peter D., Hasle, Henrik, Issa, Jean-Pierre, van den Heuvel-Eibrink, Marry M., Locatelli, Franco, Starý, Jan, Trebo, Monica, Wlodarski, Marcin, Zecca, Marco, Shannon, Kevin M., Niemeyer, Charlotte M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738571/
https://ncbi.nlm.nih.gov/pubmed/19571318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-198416
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