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Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Seventy-five percent of patients harbor mutations in the NF1, NRAS, KRAS, or PTPN11 genes,...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society of Hematology
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2738571/ https://ncbi.nlm.nih.gov/pubmed/19571318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-198416 |
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