RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia

Aberrant DNA methylation at specific genetic loci is a key molecular feature of juvenile myelomonocytic leukemia (JMML) with poor prognosis. Using quantitative high-resolution mass spectrometry, we identified RASA4 isoform 2, which maps to chromosome 7 and encodes a member of the GAP1 family of GTPa...

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Main Authors: Poetsch, Anna R, Lipka, Daniel B, Witte, Tania, Claus, Rainer, Nöllke, Peter, Zucknick, Manuela, Olk-Batz, Christiane, Fluhr, Silvia, Dworzak, Michael, De Moerloose, Barbara, Starý, Jan, Zecca, Marco, Hasle, Henrik, Schmugge, Markus, van den Heuvel-Eibrink, Marry M, Locatelli, Franco, Niemeyer, Charlotte M, Flotho, Christian, Plass, Christoph
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169017/
https://ncbi.nlm.nih.gov/pubmed/25147919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.29941
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