RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia

Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by mutations activating RAS signaling. Established clinical and genetic markers fail to fully recapitulate the clinical and biological heterogeneity of this disease. Here we report D...

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Publicado en:Nat Commun
Main Authors: Lipka, Daniel B., Witte, Tania, Toth, Reka, Yang, Jing, Wiesenfarth, Manuel, Nöllke, Peter, Fischer, Alexandra, Brocks, David, Gu, Zuguang, Park, Jeongbin, Strahm, Brigitte, Wlodarski, Marcin, Yoshimi, Ayami, Claus, Rainer, Lübbert, Michael, Busch, Hauke, Boerries, Melanie, Hartmann, Mark, Schönung, Maximilian, Kilik, Umut, Langstein, Jens, Wierzbinska, Justyna A., Pabst, Caroline, Garg, Swati, Catalá, Albert, De Moerloose, Barbara, Dworzak, Michael, Hasle, Henrik, Locatelli, Franco, Masetti, Riccardo, Schmugge, Markus, Smith, Owen, Stary, Jan, Ussowicz, Marek, van den Heuvel-Eibrink, Marry M., Assenov, Yassen, Schlesner, Matthias, Niemeyer, Charlotte, Flotho, Christian, Plass, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736667/
https://ncbi.nlm.nih.gov/pubmed/29259247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02177-w
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