RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia

Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by mutations activating RAS signaling. Established clinical and genetic markers fail to fully recapitulate the clinical and biological heterogeneity of this disease. Here we report D...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Lipka, Daniel B., Witte, Tania, Toth, Reka, Yang, Jing, Wiesenfarth, Manuel, Nöllke, Peter, Fischer, Alexandra, Brocks, David, Gu, Zuguang, Park, Jeongbin, Strahm, Brigitte, Wlodarski, Marcin, Yoshimi, Ayami, Claus, Rainer, Lübbert, Michael, Busch, Hauke, Boerries, Melanie, Hartmann, Mark, Schönung, Maximilian, Kilik, Umut, Langstein, Jens, Wierzbinska, Justyna A., Pabst, Caroline, Garg, Swati, Catalá, Albert, De Moerloose, Barbara, Dworzak, Michael, Hasle, Henrik, Locatelli, Franco, Masetti, Riccardo, Schmugge, Markus, Smith, Owen, Stary, Jan, Ussowicz, Marek, van den Heuvel-Eibrink, Marry M., Assenov, Yassen, Schlesner, Matthias, Niemeyer, Charlotte, Flotho, Christian, Plass, Christoph
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736667/
https://ncbi.nlm.nih.gov/pubmed/29259247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02177-w
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky