CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia

BACKGROUND: Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm of childhood whose clinical heterogeneity is only poorly represented by gene sequence alterations. It was previously shown that aberrant DNA methylation of distinct target genes defines a more aggressive variant of...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Fluhr, Silvia, Boerries, Melanie, Busch, Hauke, Symeonidi, Aikaterini, Witte, Tania, Lipka, Daniel B, Mücke, Oliver, Nöllke, Peter, Krombholz, Christopher Felix, Niemeyer, Charlotte M, Plass, Christoph, Flotho, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858931/
https://ncbi.nlm.nih.gov/pubmed/27158276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0216-3
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