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The Alternating Access Transport Mechanism in LacY

Lactose permease of Escherichia coli (LacY) is highly dynamic, and sugar binding causes closing of a large inward-facing cavity with opening of a wide outward-facing hydrophilic cavity. Therefore, lactose/H(+) symport via LacY very likely involves a global conformational change that allows alternati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kaback, H. Ronald, Smirnova, Irina, Kasho, Vladimir, Nie, Yiling, Zhou, Yonggang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030946/
https://ncbi.nlm.nih.gov/pubmed/21161516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-010-9327-5
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