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Structural basis for human PHF2 Jumonji domain interaction with metal ions
PHF2 belongs to a class of α-ketoglutarate-Fe(2+)–dependent dioxygenases. PHF2 harbors a plant homeodomain (PHD) and a Jumonji domain. PHF2, via its PHD domain, binds Lys4-trimethylated histone 3 (H3K4me3) in sub micromolar affinity, and has been reported to have demethylase activity of mono-methyla...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3030633/ https://ncbi.nlm.nih.gov/pubmed/21167174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.12.013 |
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