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Structural basis for the versatile and methylation-dependent binding of CTCF to DNA

The multidomain CCCTC-binding factor (CTCF), containing a tandem array of 11-zinc fingers (ZF), modulates the three-dimensional organization of chromatin. We crystallized the human CTCF DNA binding domain in complex with a known CTCF binding site. While ZF2 does not make sequence-specific contacts,...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Hashimoto, Hideharu, Wang, Dongxue, Horton, John R., Zhang, Xing, Corces, Victor G., Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542067/
https://ncbi.nlm.nih.gov/pubmed/28529057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.05.004
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