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Structural basis for the versatile and methylation-dependent binding of CTCF to DNA
The multidomain CCCTC-binding factor (CTCF), containing a tandem array of 11-zinc fingers (ZF), modulates the three-dimensional organization of chromatin. We crystallized the human CTCF DNA binding domain in complex with a known CTCF binding site. While ZF2 does not make sequence-specific contacts,...
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| Udgivet i: | Mol Cell |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5542067/ https://ncbi.nlm.nih.gov/pubmed/28529057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.05.004 |
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