Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA

The recently characterized mammalian writer (methyltransferase) and eraser (demethylase) of the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded (ss) and transiently-unpaired DNA. As YTH domain-containing proteins bind N6mA-containing RNA in mammalian cells, we investigated whether mam...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Woodcock, Clayton B, Horton, John R, Zhou, Jujun, Bedford, Mark T, Blumenthal, Robert M, Zhang, Xing, Cheng, Xiaodong
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544203/
https://ncbi.nlm.nih.gov/pubmed/32663306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa604
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