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Replication across template T/U by human DNA polymerase-ι

Human DNA polymerase-ι (Polι) incorporates correct nucleotides opposite template purines with a much higher efficiency and fidelity than opposite template pyrimidines. In fact, the fidelity opposite template T is so poor that Polι inserts an incorrect dGTP approximately 10 times better than it inser...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jain, Rinku, Nair, Deepak T., Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030472/
https://ncbi.nlm.nih.gov/pubmed/19604477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.04.011
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