A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation: REQUIREMENT FOR CARBOXYL-TERMINAL PROTEOLYTIC PROCESSING

Acid sphingomyelinase (aSMase) catalyzes the hydrolysis of sphingomyelin (SM) to form the bioactive lipid ceramide (Cer). Notably, aSMase exists in two forms: a zinc (Zn(2+))-independent lysosomal aSMase (L-SMase) and a Zn(2+)-dependent secreted aSMase (S-SMase) that arise from alternative trafficki...

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Detalhes bibliográficos
Main Authors: Jenkins, Russell W., Idkowiak-Baldys, Jolanta, Simbari, Fabio, Canals, Daniel, Roddy, Patrick, Riner, Clarke D., Clarke, Christopher J., Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030379/
https://ncbi.nlm.nih.gov/pubmed/21098024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155234
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