Regulated Secretion of Acid Sphingomyelinase: IMPLICATIONS FOR SELECTIVITY OF CERAMIDE FORMATION

The acid sphingomyelinase (aSMase) gene gives rise to two distinct enzymes, lysosomal sphingomyelinase (L-SMase) and secretory sphingomyelinase (S-SMase), via differential trafficking of a common protein precursor. However, the regulation of S-SMase and its role in cytokine-induced ceramide formatio...

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Autores principales: Jenkins, Russell W., Canals, Daniel, Idkowiak-Baldys, Jolanta, Simbari, Fabio, Roddy, Patrick, Perry, David M., Kitatani, Kazuyuki, Luberto, Chiara, Hannun, Yusuf A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975195/
https://ncbi.nlm.nih.gov/pubmed/20807762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.125609
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