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Roles and Regulation of Secretory and Lysosomal Acid Sphingomyelinase

Acid sphingomyelinase occupies a prominent position in sphingolipid catabolism, catalyzing the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Enzymatic dysfunction of acid sphingomyelinase results in Niemann-Pick disease, a lysosomal storage disorder characterized at the cellular lev...

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Bibliografiske detaljer
Main Authors: Jenkins, Russell W., Canals, Daniel, Hannun, Yusuf A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488588/
https://ncbi.nlm.nih.gov/pubmed/19385042
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