MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

Many human aneuploidy syndromes have unique phenotypic consequences, but in most instances it is unclear whether these phenotypes are attributable to alterations in the dosage of specific genes. In human trisomy 13, there is delayed switching and persistence of fetal hemoglobin (HbF) and elevation o...

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Detalhes bibliográficos
Main Authors: Sankaran, Vijay G., Menne, Tobias F., Šćepanović, Danilo, Vergilio, Jo-Anne, Ji, Peng, Kim, Jinkuk, Thiru, Prathapan, Orkin, Stuart H., Lander, Eric S., Lodish, Harvey F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029749/
https://ncbi.nlm.nih.gov/pubmed/21205891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018384108
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