14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1

14-3-3σ regulates cytokinesis and cell cycle arrest induced by DNA damage but its role in the immune system is unknown. Using gene-targeted 14-3-3σ–deficient (i.e., KO) mice, we studied the role of 14-3-3σ in B-cell functions. Total numbers of B cells were reduced by spontaneous apoptosis of periphe...

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Main Authors: Su, Yu-Wen, Hao, Zhenyue, Hirao, Atsushi, Yamamoto, Kazuo, Lin, Wen-Jye, Young, Ashley, Duncan, Gordon S., Yoshida, Hiroki, Wakeham, Andrew, Lang, Philipp A., Murakami, Kiichi, Hermeking, Heiko, Vogelstein, Bert, Ohashi, Pamela, Mak, Tak W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029705/
https://ncbi.nlm.nih.gov/pubmed/21205887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017729108
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