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Kinetics and Inhibition of Nicotinamidase from Mycobacterium tuberculosis
Nicotinamidase/Pyrazinamidase (PncA) is involved in the NAD(+) salvage pathway of Mycobacterium tuberculosis and other bacteria. In addition to hydrolyzing nicotinamide into nicotinic acid, PncA also hydrolyzes the pro-drug pyrazinamide to generate the active form of the drug, pyrazinoic acid, which...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3029496/ https://ncbi.nlm.nih.gov/pubmed/20879713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1011157 |
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