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Chemical Mechanism of the Branched-Chain Aminotransferase IlvE from Mycobacterium tuberculosis

The biosynthetic pathway of the branched-chain amino acids is essential for Mycobacterium tuberculosis growth and survival. We report here the kinetic and chemical mechanism of the pyridoxal 5′-phosphate (PLP)-dependent branched-chain aminotransferase, IlvE, from M. tuberculosis (MtIlvE). This enzym...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Amorim Franco, Tathyana M., Hegde, Subray, Blanchard, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443349/
https://ncbi.nlm.nih.gov/pubmed/27780341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00928
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