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Kinetics and Inhibition of Nicotinamidase from Mycobacterium tuberculosis

Nicotinamidase/Pyrazinamidase (PncA) is involved in the NAD(+) salvage pathway of Mycobacterium tuberculosis and other bacteria. In addition to hydrolyzing nicotinamide into nicotinic acid, PncA also hydrolyzes the pro-drug pyrazinamide to generate the active form of the drug, pyrazinoic acid, which...

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Detalhes bibliográficos
Main Authors: Seiner, Derrick R., Hegde, Subray S., Blanchard, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029496/
https://ncbi.nlm.nih.gov/pubmed/20879713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1011157
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