Defective Molecular Timer in the Absence of Nucleotides Leads to Inefficient Caspase Activation

In the intrinsic death pathway, cytochrome C (CC) released from mitochondria to the cytosol triggers Apaf-1 apoptosome formation and subsequent caspase activation. This process can be recapitulated using recombinant Apaf-1 and CC in the presence of nucleotides ATP or dATP [(d)ATP] or using fresh cyt...

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Bibliografiske detaljer
Main Authors: Zhang, Honghao, Gogada, Raghu, Yadav, Neelu, Lella, Ravi K., Badeaux, Mark, Ayres, Mary, Gandhi, Varsha, Tang, Dean G., Chandra, Dhyan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029307/
https://ncbi.nlm.nih.gov/pubmed/21297999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016379
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