Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer

Cytochrome c (Cyt c) released from mitochondria interacts with Apaf-1 to form the heptameric apoptosome, which initiates the caspase cascade to execute apoptosis. Although lysine residue at 72 (K72) of Cyt c plays an important role in the Cyt c-Apaf-1 interaction, the underlying mechanism of interac...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta Mol Cell Res
Main Authors: Yadav, Neelu, Gogada, Raghu, O’Malley, Jordan, Gundampati, Ravi Kumar, Jayanthi, Srinivas, Hashmi, Sana, Lella, Ravi, Zhang, Dianmu, Wang, Jianmin, Kumar, Rahul, Thallapuranam, Suresh Kumar, Chandra, Dhyan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733678/
https://ncbi.nlm.nih.gov/pubmed/31678591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2019.118573
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